Localization of the Clostridium difficile cysteine protease Cwp 84 and insights 1 into its maturation process
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2 Service de Microbiologie, Hôpital Jean Verdier, Assistance Publique-Hôpitaux de Paris, 8 France 9 10 11 Running title: Localization and maturation process of Cwp84 of Clostridium difficile 12 13 * Corresponding author: 14 Claire Janoir 15 Université Paris-Sud 11, Faculté de Pharmacie, Département de Microbiologie, 16 5 rue Jean Baptiste Clément, 92296 Châtenay-Malabry Cedex, France. 17 Phone: + 33 1 46 83 56 34. 18 Fax: + 33 1 46 83 55 37. 19 E-mail: [email protected] 20 21 22 23 Copyright © 2011, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved. J. Bacteriol. doi:10.1128/JB.00326-11 JB Accepts, published online ahead of print on 22 July 2011
منابع مشابه
Localization of the Clostridium difficile cysteine protease Cwp84 and insights into its maturation process.
Clostridium difficile is a nosocomial pathogen involved in antibiotic-associated diarrhea. C. difficile expresses a cysteine protease, Cwp84, which has been shown to degrade some proteins of the extracellular matrix and play a role in the maturation of the precursor of the S-layer proteins. We sought to analyze the localization and the maturation process of this protease. Two identifiable forms...
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تاریخ انتشار 2011